Research Project

Project Title:

Set-up of a platform for personalized diagnosis of rare kidney diseases (NIKE)

Project Type:

Translational research

Disease group(s):

Hereditary glomerulopathies, Pediatric CKD & dialysis

Project Summary:

This project aims to: 1. Propose an integrated diagnostic algorithm to extend novel strategies of personalized diagnosis at european
level; 2. Promote implementation of personalized diagnosis of CKD with constant update of the panel of genes analysed in real-time ;
3. Support personalized diagnosis with implementation of individual disease modelling from 2D to 3D organ-on a chip; 4. Mapping
pathways for drug targeting in orphan kidney diseases by single cell RNA sequencing 5. Set-up preclinical gene editing approaches for
personalized treatment of selected kidney disorders.

Lead principal investigator(s):

Paola Romagnani, Florence

Co-investigator(s):

Alessandra Renieri, Siena
Sabrina Giglio, Florence
Elena Lazzeri, Florence
Francesca Egidi, Maria
Alberto Rosati, Florence

Project Period:

07/2020   -   06/2023

Sponsors:

Regional funding agency

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