Research Project

Project Title:

Phenotypic and functional characterization of lymphocytes, monocytes, and macrophages by flow cytometry of urinary sediment in patients with lupus nephritis for the prediction of chronic kidney disease

Project Type:

Translational research

Disease group(s):

Immune glomerulopathies

Project Summary:

Persistent renal inflammation in patients with lupus nephritis (LN) leads to interstitial fibrosis and tubular atrophy, the main denominators of chronic kidney disease (CKD) progression. The detection and quantification of the subtypes of T and B lymphocytes and macrophages, the main effector cells of kidney damage, may be a potential non-invasive predictive biomarker of CKD in these patients. In this prospective observational study, 3 techniques for determining the risk of progression to advanced CKD in patients with LN will be compared. The study subjects will be patients with LN undergoing renal biopsy for clinical indication, or control when they are in clinical remission. Flow cytometric analysis of kidney tissue and urine will be performed, analyzing subtypes for T cells, B cells, TBNK panel, and M1 and M2 macrophage panel. The findings will be correlated with the histological results, clinical and laboratory data, and their predictive capacity for clinical evolution at 24-month follow-up will be evaluated.

Lead principal investigator(s):

Luis Quintana, Barcelona


Marc Xipell, Barcelona

Project Period:

01/2021   -   12/2024


National funding agency

« Back to research page