Research Project

Project Title:	Protection from reactive metabolites in CKD and diabetes
Project Type:	Translational research
Disease group(s):	Metabolic & stone disorders
Project Summary:	The group is a collaborative research center in the SFB 1118 of the German Research Foundation; the project is focused on the histidin dipeptide metabolism and the protective mechanisms against reactive metabolites. A carnosinase 1 (CN1) ko mouse model with different forms of diabetes and renal disease and an iron overload mouse model are currently analyzed. Visualization of vascular and glomerular effects and biochemical characterization is performed in various zebra fish models. Upcoming studies address the role of CN2 in diabetes and CKD.
Lead principal investigator(s):	Claus Peter Schmitt, Heidelberg Verena Peters, Heidelberg
Project Period:	01/2014 - 01/2022
Sponsors:	National funding agency
Project web page:	https://www.klinikum.uni-heidelberg.de/Willkommen.132204.0.html