Research Project

Project Title:	CUREiHUS
Project Type:	Observational Study, Enrolment ongoing Adjunct biobank: DNA, Serum, Plasma
Disease group(s):	Thrombotic microangiopathies
Project Summary:	Recently, the national, prospective study called CUREiHUS (Full project title: National observational study to monitor the new guideline concerning treatment of patients with atypical hemolytic uremic syndrome, NTR5988) has started in the Netherlands. This study will include all aHUS patients and will monitor and evaluate the restrictive treatment regimen according the new Dutch guideline. With the CUREiHUS study we hope to show that a restrictive treatment regimen is feasible. Moreover, we want to investigate the potential efficacy of this new treatment regimen from a societal perspective with the design of a cost-effectiveness analysis. Furthermore, we will look into the pharmacokinetics and dynamics of eculizumab
Lead principal investigator(s):	Nicole vandeKar, Nijmegen Jack Wetzels, Nijmegen
Project Period:	10/2016 - 10/2022
Sponsors:	National funding agency
Project web page:	www.cureihus.nl
ClinicalTrials.gov:	NTR5988