Research Project

Project Title:

Systems Multiomics Approach for Precision Diagnostics of Idiopathic Nephrotic Syndrome

Project Type:

Translational research

Disease group(s):

Immune glomerulopathies

Project Summary:

Idiopathic nephrotic syndrome (INS) is a group of rare glomerulopathies of unclear etiology,
characterized by severe proteinuria, oedema and extensive podocyte injury. INS is currently
treated with corticosteroids and immunosuppressants, which cause severe side effects. Many
patients manifest treatment resistance or dependence, conferring a high risk of progression to
end-stage renal failure. INS often recurs after transplantation, causing premature graft loss,
presumably due to one or more circulating permeability factor(s), still unidentified. At present
there are no specific diagnostic biomarkers or predictive of post-transplant recurrence, seriously
hampering novel drug development and treatment strategies.
Our consortium brings together a unique combination of clinical and research experts in INS,
global analysis technologies and cutting-edge models. This project aims to apply our latest
findings and technological developments to unveil reliable biomarker profiles of post-transplant
recurrence, allowing a better stratification for precise intervention. Our aims are: (i) to search for
new relevant biomarkers by untargeted multiomics on a retrospective cohort; (ii) to validate the
potential of the new candidate signatures on a prospective cohort and that of a newly
developed podocyte morphometry test; (iii) to develop pre-clinical INS models and endpoints
that could either constitute biomarkers and/or contribute to biomarker validation. The proposed
program will provide new tools for precision medicine, contributing to improved treatment and
disease monitoring.

Lead principal investigator(s):

Mario Ollero, Paris


Rutger Maas, Nijmegen
Ben Smeets, Nijmegen, Netherlands
Laura Garcia-Bermejo, Madrid, Spain
Marie Lhomme, Paris, France

Project Period:

01/2022   -   12/2025


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