Current research projects
Clinical Trials
Glomerulopathies
- A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Ravulizumab in Adult Participants With Immunoglobulin A Nephropathy (IgAN) (ICAN)
- An Open-Label, Nonrandomized, Multicenter Extension Study to Evaluate the Long-term Safety and Efficacy of Pegcetacoplan in Patients With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis (VALE)
- A Phase 2b/3, Multi-part, Randomized, Double-Blinded, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Atacicept in Subjects With IgA Nephropathy (IgAN) (ORIGIN 3)
- A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy and Safety of Sibeprenlimab Administered Subcutaneously in Subjects With Immunoglobulin A Nephropathy.
- Metformin versus Tolvaptan in adults with Autosomal Dominant Plycystic Kidney Disease: a phase 3a, indipendent, multi-centre, 2 parallel arms randomized-controlled trial
- 18-month, open-label, single-arm safety extension study of an age and bodyweightadjusted oral finerenone regimen, in addition to an ACEI or ARB, for the treatment of children and young adults (1 to 18 years) with chronic kidney disease and proteinuria
- A Phase 2, Open-Label, Basket Study of Atrasentan in Patients With Proteinuric Glomerular Diseases (AFFINITY)
- A Phase II, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescent Patients With Active Class III or IV Lupus Nephritis
- A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study To Evaluate The Efficacy And Safety Of Obinutuzumab In Patients With ISN/RPS 2003 Class III Or IV Lupus Nephritis (REGENCY)
- The FIONA Study
- Obinutuzumab in Primary MN (ORION)
- A 9-year, Multicentre, Non-interventional, Post-authorisation Safety Study for Patients Prescribed JINARC® for Autosomal Dominant Polycystic Kidney Disease (JINARC-PASS)
- A multicenter, randomized, double-blind, parallel group, placebo-controlled study to evaluate the efficacy and safety of iptacopan (LNP023) in complement 3 glomerulopathy
- Phase 3 study to evaluate the efficacy and safety of LNP023 on proteinuria and renal function decline in primary IgA nephropathy patients
- A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Ravulizumab in Adult Participants With Proliferative Lupus Nephritis (LN) or Immunoglobulin A Nephropathy (IgAN) (SANCTUARY)
- A Phase III Randomized, Open-Label Active Comparator-Controlled Multicenter Study to Evaluate Efficacy and Safety of Obinutuzumab in Patients With Primary Membranous Nephropathy (MAJESTY)
- Study Assessing the Safety and Efficacy of Pegcetacoplan in Post-Transplant Recurrence of C3G or IC-MPGN (NOBLE)
- A Phase 3, Randomized, Double-blind, Placebocontrolled Study of Atrasentan in Patients with IgA Nephropathy at Risk of Progressive Loss of Renal Function (The ALIGN Study)
- A Phase 3, Randomized, Double-blind, Multicenter, Placebo Controlled Study of Inebilizumab Efficacy and Safety in IgG4-Related Disease (MITIGATE)
- A Randomized, Multicenter, Double-blind, Parallel-group, Active-control Study of the Efficacy and Safety of Sparsentan for the Treatment of Immunoglobulin A Nephropathy
- An Open-label, Non-randomized Extension Study to Evaluate the Long-term Efficacy, Safety and Tolerability of Iptacopan (LNP023) in C3 Glomerulopathy or Idiopathic Immune-complex-membranoproliferative Glomerulonephritis
- A Randomized, Multicenter, Double-blind, Parallel-group, Active-control Study of the Efficacy and Safety of Sparsentan for the Treatment of Immunoglobulin A Nephropathy
- AN EXTENDED ACCESS PROGRAM TO ASSESS LONG TERM SAFETY OF BARDOXOLONE METHYL IN PATIENTS WITH CHRONIC KIDNEY DISEASE (EAGLE)
- A randomized, multicenter, double-blind, parallel, active-control study of the effects of Sparsentan, a dual endothelin receptor and angiotensin receptor blocker, on renal outcomes in patients with primary focal segmental glomerulosclerosis (DUPLEX)
- LEARNS: Levamisole as Adjuvant therapy to Reduce relapses of Nephrotic Syndrome
- Genetic, genomic, and biomarker studies of Henoch-Schönlein purpura and IgA nephropathy in kids
Tubulopathies and metabolic disorders
- Efficacy and Safety of SGLT2-i in Fanconi Bickel Syndrome, ERKNET and MetabERN join project
- Development of a Patient-reported Outcome to Measure the Health-related Quality of Life of Children, Adolescents and Young Adults With Cystinosis (QUALIFY)
- Scientific Basis for a Newborn Screening for Cystinosis and Primary Hyperoxaluria (GENESIS)
- OCULAR BIOMARKERS - Validation of ocular OCT-based biomarkers for corneal and systemic disease activity in infantile nephropathic cystinosis
- A Phase 2 Open-Label Study to Evaluate the Safety and Efficacy of DCR-PHXC in Patients With Primary Hyperoxaluria Type 1 and Severe Renal Impairment, With or Without Dialysis (PHYOX)
- ILLUMINATE-C: A Single Arm Study to Evaluate Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Lumasiran in Patients With Advanced Primary Hyperoxaluria Type 1 (PH1)
- Roll over study to evaluate the safety and long term efficacy of DCR-PHXC in patient with Primary Hyperoxaluria (DCR-PHXC-301)
Thrombotic microangiopathies
- A Phase III, Multicenter, Single-Arm Study Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab in Pediatric Patients With Atypical Hemolytic Uremic Syndrome (aHUS)
- Tailorig Complement inhibition for Thrombotic microangiopathies
- A Multicenter, Single-arm, Open Label Trial to Evaluate Efficacy and Safety of Oral, Twice Daily LNP023 in Adult aHUS Patients Who Are Naive to Complement Inhibitor Therapy (APPELHUS)
- A Phase III, Multicenter, Single-Arm Study Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab in Pediatric Patients With Atypical Hemolytic Uremic Syndrome(aHUS)
Structural Kidney Disorders
- 18-month, open-label, single-arm safety extension study of an age and bodyweightadjusted oral finerenone regimen, in addition to an ACEI or ARB, for the treatment of children and young adults (1 to 18 years) with chronic kidney disease and proteinuria
- The FIONA Study
CKD and Dialysis in Children
- A Phase 3, Open-label, Uncontrolled Study to Evaluate the Activity, Safety, Pharmacokinetics and Pharmacodynamics of Roxadustat for the Treatment of Anemia in Pediatric Participants With Chronic Kidney Disease
- Development, validation and clinical reliability of a predictive machine learning model for volume management in pediatric intensive care unit
- The FIONA Study
- Phase 3, Single-arm, Open-label, Multidose, Titration, Pharmacokinetic, Pharmacodynamic, and Safety Study of Etelcalcetide in Children and Adolescents With Secondary Hyperparathyroidism and Chronic Kidney Disease Receiving Maintenance Hemodialysis
Pediatric Kidney Transplantation
- A Study to Evaluate the Benefits and Risks of Conversion of Existing Adolescent Kidney Transplant Recipients Aged 12 to <18 Years to a Belatacept-based Immunosuppressive Regimen as Compared to Continuation of a Calcineurin Inhibitor-based Regimen
- ProTac Study
- 18-month, open-label, single-arm safety extension study of an age and bodyweightadjusted oral finerenone regimen, in addition to an ACEI or ARB, for the treatment of children and young adults (1 to 18 years) with chronic kidney disease and proteinuria
- A Phase II, randomised, open-label, multicentre study to assess the reactogenicity, safety and immunogenicity of GSK's paediatric Herpes Zoster subunit candidate vaccine (PED-HZ/su) when administered intramuscularly on a two-dose schedule to immunocomprom
Cohort Studies and Registries
Glomerulopathies
- ERKReg Subregistry on IgA Nephropathy and IgA Vasculitis
- ERKReg Subregistry on ANCA Associated Vasculitis
- The CompCure Project and ERKReg Registry
- Fabry Disease Registry Protocol
- ERKReg Subregistry on Pediatric SLE
- PREGeNEPH Registry - Pregnany, Genetics & Nephrology
- Magnetic resonance Imaging of Cysts KidneY Volume and microstructure in ADPKD patients: a retrospective study
- Global Kidney Patient Trials Network (GKPTN2019)
- Registro italiano ADPKD
- Evaluation of immune competence in children with idiopathic nephrotic syndrome
- GeNepher registry and biobank
- ERKReg (The European Rare Kidney Disease Registry)
- PodoNet
Tubulopathies and metabolic disorders
- ODAP (Orphan Drug Access protocol lumasiran)
- Stable isotopes in calcium-oxalate stone formers
- ERKReg Subregistry on Bartter/Gitelman
- Renal involvement in Coffin Siris syndrome
- SENTENCE - Structured multidisciplinary data collection for cystinosis
- PREGeNEPH Registry - Pregnany, Genetics & Nephrology
- ERKReg Subregistry on Cystinuria (EUROCYS Registry)
- Natural history of patients with dRTA
- GeNepher registry and biobank
- International XLH Registry
- ERKReg Subregistry on dRTA
- ERKReg (The European Rare Kidney Disease Registry)
- European Cystinosis Cohort (RaDiCo-ECYSCO)
- Chitotriosidase as a novel biomarker of cystinosis
Thrombotic microangiopathies
- Anti Factor A antibody aHUS treated with complement blocking theraphy only
- PREGeNEPH Registry - Pregnany, Genetics & Nephrology
- GeNepher registry and biobank
- ERKReg (The European Rare Kidney Disease Registry)
- aHUS REGISTRY
Structural Kidney Disorders
- ERKReg Subregistry on ADTKD
- FEMALE_PKD: abordando la poliquistosis renal autosómica dominante desde una perspectiva de género
- ADTKD-Net
- AUTOSOMAL DOMINANT TUBULOINTERSTITIAL KIDNEY DISEASE-Net A European registry based clinical research platform
- ERKNet Survey on clinical manifestations and renal outcome in HNF1beta
- Late onset PKAR (> 18 years old): phenotype, gentoype and evolution
- Renal damage and evolution of kidney function in patients with Kabuki syndrome
- PREGeNEPH Registry - Pregnany, Genetics & Nephrology
- ArtDeco
- GeNepher registry and biobank
- ERKReg (The European Rare Kidney Disease Registry)
- ADPedKD: an international web-based database for longitudinal data registry of children with autosomal dominant polycystic kidney disease (ADPKD).
- AD(H)PKD - Evaluating ADPKD in the era of tolvaptan
CKD and Dialysis in Children
- The CompCure Project and ERKReg Registry
- European Registry for Children on Renal Replacement Therapy - ESPN-ERA Registry
- GeNepher registry and biobank
- ERKReg Subregistry esCapeKD
- ERKReg (The European Rare Kidney Disease Registry)
- International Peritoneal Biobank
- International Pediatric Dialysis Network (IPDN)
Pediatric Kidney Transplantation
Translational Research Projects
Glomerulopathies
- Genome and transcriptome study in patients with non-associated nephropathy with suspected monogenic cause
- A needle in a haystack.: indentifying unsuspected inherited kidney diseases
- Searching unsuspected inherited kidney diseases: a needle in a haystack (NLP)
- Systems Multiomics Approach for Precision Diagnostics of Idiopathic Nephrotic Syndrome
- Elucidating the genetic pathomechanism underlying rare and hereditary kidney diseases (RKD)
- Urinary Biomarkers: Analysis of Urine in patients with tubular and glomerular kidney disease
- Renal Biopsy Project
Tubulopathies and metabolic disorders
- Genome and transcriptome study in patients with non-associated nephropathy with suspected monogenic cause
- A needle in a haystack.: indentifying unsuspected inherited kidney diseases
- Effect of diet in animal models of nephropathic cystinosis (Evaluation)
- Ketogenic diet for nephropathic cystinosis
- RNA therapy in cystinosis
- Searching unsuspected inherited kidney diseases: a needle in a haystack (NLP)
- ACTIVITIES OF FLAVONOID LUTEOLIN IN A MOUSE MODEL OF NEPHROPATHIC CYSTINOSIS
- Elucidating the genetic pathomechanism underlying rare and hereditary kidney diseases (RKD)
- Urinary Biomarkers: Analysis of Urine in patients with tubular and glomerular kidney disease
Thrombotic microangiopathies
- Searching unsuspected inherited kidney diseases: a needle in a haystack (NLP)
- Elucidating the genetic pathomechanism underlying rare and hereditary kidney diseases (RKD)
- Urinary Biomarkers: Analysis of Urine in patients with tubular and glomerular kidney disease
Structural Kidney Disorders
- Genome and transcriptome study in patients with non-associated nephropathy with suspected monogenic cause
- Theracil EU consortium
- A needle in a haystack.: indentifying unsuspected inherited kidney diseases
- Searching unsuspected inherited kidney diseases: a needle in a haystack (NLP)
- Aetiology of renal and urinary tract anomalies defines Diagnostic Efficacy and Clinical Outcome
- NeoCyst
- Elucidating the genetic pathomechanism underlying rare and hereditary kidney diseases (RKD)
- Urinary Biomarkers: Analysis of Urine in patients with tubular and glomerular kidney disease
CKD and Dialysis in Children
- Theracil EU consortium
- NPHP1-consortium
- Elucidating the genetic pathomechanism underlying rare and hereditary kidney diseases (RKD)
- Urinary Biomarkers: Analysis of Urine in patients with tubular and glomerular kidney disease