Research Project

Project Title:

Prevention of relapses with levamisole as adjuvant therapy in children with a first episode idiopathic nephrotic syndrome (LEARNS).

Project Type:

Clinical Trial, Enrolment ongoing
Adjunct biobank: DNA, Serum, Plasma, Urine

Disease group(s):

Immune glomerulopathies

Project Summary:

Minimal change nephropathy (MCN) is the most common cause of idiopathic nephrotic syndrome (INS) in children. The main hypothesis of the LEARNS trial is that combined treatment of children with a first episode of INS with steroids and levamisole will prevent relapses after the initial episode of INS compared to single treatment with steroids alone. This will be tested in a multicenter, randomised, double-blind placebo-controlled trial (RCT).

Lead principal investigator(s):

Antonia Bouts, Amsterdam

Project Period:

04/2018   -   04/2022


Non-profit foundation, National funding agency

Project web page:

EudraCT Nr.:


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