Research Project

Project Title:	Solitary Functioning Kidney: Aetiology and Prognosis (SOFIA)
Project Type:	Observational Study, Enrolment terminated Adjunct biobank: DNA, Urine
Disease group(s):	Congenital malformations & ciliopathies
Project Summary:	Congenital solitary functioning kidney (SFK) affects ~1 in 2,000 children. Given the observed familial clustering, congenital SFK is most likely a multifactorial disorder. Children can also acquire an SFK after unilateral nephrectomy. Children with either form of SFK are frequently monitored because up to 50% of affected children may have progressive renal disease, ultimately ending in endstage renal disease. In the SOFIA Project, we aim to improve guidance of SFK patients and their families by: 1. Improving information about causal factors for congenital SFK. 2. Predicting which children with an SFK will develop renal injury later in life. 3. Identifying biomarkers for early detection of renal injury in SFK. Children with an SFK were recruited in >30 hospitals throughout the Netherlands. From these patients, DNA, information on environmental exposures before and during pregnancy, and clinical information was gathered
Lead principal investigator(s):	Michiel Schreuder, Nijmegen Loes Zanden van der , Nijmegen
Co-investigator(s):	Wout Feitz, Nijmegen Nel Roeleveld, Nijmegen
Project Period:	06/2018 - 06/2022
Sponsors:	Local resources
Project web page:	https://www.mononier.nl/