Jack Wetzels

Jack F M Wetzels studied Medicine at the University of Nijmegen, and received his MD in 1980. He undertook his training in Internal medicine and Nephrology at the Radboud University Nijmegen Medical center. He received his Ph.D. in 1989.  From 1990 to 1992 he studied ischemic renal tubular injury as a postdoctoral fellow under supervision of Robert W Schrier at the University of Colorado Health Sciences Center in Denver, CO, USA. Since 1992 he is working as nephrologist and in 2002 he was appointed Professor of Nephrology in the Department of Nephrology at Radboud University Nijmegen. His chair is committed to teaching and research with an emphasis on the diagnosis and treatment of patients with glomerular diseases. I participated in the development of the KDIGO guidelines for glomerular diseases (2012 and 2020).


The team of experts at Radboudumc Department of Nephrology has a long standing history of taking care of adult patients with rare kidney disease. In this team we educate junior faculty, fellows, nurses, and laboratory researchers.

Over the past 30 years we have gained expertise in primary glomerular diseases associated with nephrotic syndrome, in complement mediated kidney disorders, in kidney disease associated with systemic diseases (vasculitis, SLE, MGRS), and in genetic kidney diseases. We more recently have added expertise in the rare tubulopathies, with dr T Nijenhuis as supervisor.

Our mission is to provide personalized care, with treatment guided by individual patient characteristics. We are active in performing research directed at the use of biomarkers for diagnosis, prognosis, and treatment. Specific areas of research are  membranous nephropathy, focal segmental glomerulosclerosis, minimal change disease, atypical HUS, C3GN, lupus nephritis, and the sodium, phosphate and magnesium wasting tubulopathies.

There is a close collaboration with the departments of pediatric nephrology, genetics, and pathology. We are active in meetings with representatives of the kidney disease patient organisation.