Research Project

Project Title:	A PHASE 2 OPEN-LABEL STUDY TO EVALUATE THE EFFICACY OF ALLOGENEIC HUMAN CORD BLOOD-DERIVED MESENCHYMAL STROMAL CELLS IN MAINTAINING REMISSION AFTER IMMUNOSUPPRESSIVE THERAPY WITHDRAWAL IN PEDIATRIC PATIENTS WITH STEROID-DEPENDENT NEPHROTIC SYNDROME
Project Type:	Clinical Trial, Enrolment ongoing
Disease group(s):	Immune glomerulopathies
Project Summary:	The main goal of the present study is to assess whether CF-CB-MSCs have the capacity to regulate the immunologic mechanisms involved in the pathogenesis of NS allowing for a reduction or suspension of chronic immunosuppressive treatment in SDNS children. The primary objective is to evaluate whether CF-CB-MSC therapy is able to prevent NS recurrence for at least 6 months after completewithdrawal of immunosuppressive treatment in children with SDNS.
Lead principal investigator(s):	Giovanni Montini, Milan
Co-investigator(s):	William Morello, Milan
Project Period:	03/2018 - 02/2023
Sponsors:	Local resources
EudraCT Nr.:	2018-001162-42