Research Project

Project Title:


Project Type:

Adjunct biobank: DNA

Disease group(s):

Congenital malformations & ciliopathies

Project Summary:

The ArtDeco consortium is a Dutch Kidney Foundation consortium around congenital abnormalities of the kidney and urinary tract.

Understanding the molecular aetiology is the key to devising personalized medicine strategies that change this alarming situation for individuals with CAKUT. Since the aetiology of CAKUT remains unknown in ≥80% of children4,5, the outcome remains unconnected to the underpinnings of developmental kidney defects for most patients. The low diagnostic yield also prevents clinicians from performing standardized genetic testing in CAKUT patients, which in return hampers additional gene discovery and better understanding of the disease aetiology. Since we integrate state-of-the-art molecular techniques and clinical data6, the ArtDECO consortium is indispensable for moving the clinical management of CAKUT patients forward.

Central hypothesis and aims
Better understanding of the molecular aetiology of CAKUT leads to a better clinical outcome for patients.

The ArtDECO consortium aims to identify the missing links between causes and prognosis of CAKUT by:
1- Establishment of a nation-wide CAKUT data- and biobank;
2- Identification and functional characterization of genetic and environmental causes;
3- Gene-environment risk modelling and prediction of clinical outcome.

Lead principal investigator(s):

Rik Westland, Amsterdam


Albertien vanEerde, Utrecht
Jaap Mulder, Rotterdam
Michiel Schreuder, Nijmegen
Nine Knoers, Groningen

Project Period:

01/2022   -   01/2027


Non-profit foundation

Project web page:

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