Research Project

Project Title:	Set-up of a platform for personalized diagnosis of rare kidney diseases (NIKE)
Project Type:	Translational research
Disease group(s):	Hereditary glomerulopathies, Pediatric CKD & dialysis
Project Summary:	This project aims to: 1. Propose an integrated diagnostic algorithm to extend novel strategies of personalized diagnosis at european level; 2. Promote implementation of personalized diagnosis of CKD with constant update of the panel of genes analysed in real-time ; 3. Support personalized diagnosis with implementation of individual disease modelling from 2D to 3D organ-on a chip; 4. Mapping pathways for drug targeting in orphan kidney diseases by single cell RNA sequencing 5. Set-up preclinical gene editing approaches for personalized treatment of selected kidney disorders.
Lead principal investigator(s):	Paola Romagnani, Florence
Co-investigator(s):	Alessandra Renieri, Siena Sabrina Giglio, Florence Elena Lazzeri, Florence Maria Francesca Egidi, Pisa Alberto Rosati, Lucca
Project Period:	07/2020 - 06/2023
Sponsors:	Regional funding agency