I trained in Medicine and in Pediatrics at the University of Pavia, Italy. I completed a Research Fellowship at Harvard University-Children’s Hospital Boston, focusing on B cell biology in murine models. Since 2006, I have been a Consultant in Pediatric Nephrology in the Division of Nephrology of Bambino Gesù Children’s Hospital and Research Center, focusing on the clinical care of children with immune-mediated kidney diseases. My research has focused on nephrotic syndrome and its underlying B cell abnormalities, and on the role of complement inhibition in complement-mediated kidney diseases. In 2017, I spent a year as Visiting Consultant in London, at Great Ormond Street Hospital, focusing on the methodology of clinical trials in children.

Since 2023, I head the Laboratory of Nephrology and the Clinical Trial Center of the Bambino Gesù Children’s Hospital.

I co-chair the ERKNet Working Group on TMAs and its Registry, IPNA guidelines for CNS, SRNS, SSNS and IgAN/V, KDIGO Guidelines of glomerular diseases and NKF and KDIGO projects on complement-mediated renal diseases. I am a Fellow of the ESPN and on the Scientific Advisory Board of ERA, member of the Editorial Board of KI and JASN.

Since 2025, I have also been nominated by the Italian Drug Agency, AIFA, as member of the National Pediatric Ethics Committee and by the Italian Ministry of Health as member of the Consiglio Superiore di Sanità, the Minister’s expert consulting committee.